Registration Dossier
Registration Dossier
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EC number: 204-616-2 | CAS number: 123-30-8
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 29 June, 2005 to 02 August 2005
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- ca. -0.09
- Temp.:
- 25 °C
- pH:
- ca. 7.5
- Remarks on result:
- other: +/- 0.01 for log Pow and +/- 0.1 for temperature and pH
- Details on results:
- HPLC: As two peaks corresponding to the test item were detected close to the peak of dead volume, the estimation of log Pow using this method was not performed.
Shake Flask: For each ratio value, the concentration of p-Aminophenol (A016) in each phase was in good
agreement with the theoretical concentration of the stock solution. The pH values of the aqueous phases at the end of the shaking were 7.5 ± 0.1. For each ratio value, the concentration of p-Aminophenol (A016) in each phase was in good agreement with the theoretical concentration of the stock solution. - Conclusions:
- Based on shake-flask method: log Pow = - 0.09 ± 0.01 at 25°C ± 1°C.
Reference
Description of key information
The key study finding was log Pow at -0.09 at 25C and pH 7.5. The supporting experimental finding was log Pow < 0.3 at 25C. A log Kow of 0.04 was reported in a secondary source included as a supporting study.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -0.09
- at the temperature of:
- 25 °C
Additional information
There is one key study and one supporting study from experimental reports. A second supporting study was included from a secondary reference source.
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