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Registration Dossier
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EC number: 204-616-2 | CAS number: 123-30-8
Dissociation constant
Administrative data
Link to relevant study record(s)
- Endpoint:
- dissociation constant
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data from handbook or collection of data
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- No method description is provided but a standard method is likely.
- GLP compliance:
- not specified
- Dissociating properties:
- yes
- No.:
- #1
- pKa:
- 5.48
- Temp.:
- 25 °C
- No.:
- #2
- pKa:
- 10.46
- Temp.:
- 25 °C
- Conclusions:
- 4- Aminophenol is amphoteric with both amine and hydroxyl functional groups; pKa values for these groups are 5.48 and 10.46, respectively. At environmental pH values from 5 to 9, the substance is expected to exist primarily as the neutral species.
Reference
Description of key information
4- Aminophenol is amphoteric with both amine and hydroxyl functional groups; pKa values for these groups are 5.48 and 10.46, respectively. At environmental pH values from 5 to 9, the substance is expected to exist primarily as the neutral species.
Key value for chemical safety assessment
- pKa at 20°C:
- 5.48
Additional information
4- Aminophenol is amphoteric with both amine and hydroxyl functional groups; pKa values for these groups are 5.48 and 10.46, respectively. At environmental pH values from 5 to 9, the substance is expected to exist primarily as the neutral species.
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