Registration Dossier

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Non-guideline and non-GLP study reporting on the acute intraperitoneal toxicity of a 50% zirconyl acetate solution. Limited information on test substance and methods employed.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1950

Materials and methods

Test guideline
Qualifier:
no guideline followed
GLP compliance:
no
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): zirconyl acetate



Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals and environmental conditions:
TEST ANIMALS
- Age at study initiation: adult rats
- Weight at study initiation: between 200 and 300 g
- Fasting period before study: no data
- Housing: maintained in air-conditioned rooms
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
water
Details on exposure:
50 aqueous solutions were used.
Doses:
Single dose, no more data
No. of animals per sex per dose:
24 rats in total
Control animals:
no
Details on study design:
- Duration of observation period following administration: 10 days
Statistics:
The LD50 values were obtained from ten day mortality data by using the log-probability method.

Results and discussion

Effect levelsopen allclose all
Sex:
male/female
Dose descriptor:
LD50
Effect level:
300 mg/kg bw
Based on:
test mat.
Sex:
male/female
Dose descriptor:
LD50
Effect level:
122 mg/kg bw
Based on:
element
Remarks:
Zr
Mortality:
The rats showed a progressive depression and decrease in activity until death occurred. The toxicity was considerably greater when zirconyl acetate was administered intraperitoneally (compared to the oral gavage route).

Clinical signs:
No characteristic physiologic changes were observed.
Body weight:
No characteristic physiologic changes were observed.
Gross pathology:
No characteristic gross pathologic changes were observed.

Applicant's summary and conclusion

Conclusions:
The acute LD50 value via the intraperitoneal route in rats is 300 mg/kg bw.