Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-824-2 | CAS number: 74-95-3
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Two in vitro Bacterial mutagenicity assays (with and without metabolic activation) and two in vitro chromosome aberration tests are available for dibromomethane. The results of these studies showed positive evidence of mutagenicity. Dibromomethane was reported to be mutagenic in some strains of Salmonella typhimurium (TA 100) and in E. coli (WU 361089 and k39) without metabolic activation and in TA 100 with metabolic activation. Dibromomethane was considered clastogenic in chromosome aberration test using human lymphocytes and increases d the aberration ratio/cell in Chinese Hamster cells.
Dibromomethane was reported not mutagenic inDrosophila melanogastersex-linked recessive lethal study.
Short description of key information:
Wright, N.P, R.Durward, Chromosome Aberation Test in Human Lymphocytes in Vitro, Safepharm Lab. UK, 19, 0466/0262, 2007
Strobel, K Toxicol. Environ. Chem. 1987, 13(3-4), 205-221
Simmon, V.F., Dev. Toxicol. Environ. Sci, 1977, 2, 249; Rapson,W.H. Bull.Environ.Contam.Toxicol.1980,24,590; von Bladenen,P.J Mutat.Res.1980,74,341
Endpoint Conclusion: Adverse effect observed (positive)
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
