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Diss Factsheets
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EC number: 252-899-6 | CAS number: 36177-92-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Irritation studies for the skin and eye are available with the test item applied in a 1% aqueous solution. The outcome does not lead to a classification. However, there is evidence of a skin and eye strong irritation/corrosion potential derived from other studies.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The irritating/corrosive potential of the substance was not observed in animal studies perfomed for the endpoints skin and eye irritation/corrosion. However, based on the outcome of studies performed for other toxicological endpoints, the strong irritating/corrosive potential of the substance became evident.
In the range finding experiments for the skin sensitization study the guinea pigs received a topical application of the test material at concentrations of 10, 25, 50 and 75% w/v in sterile water. Each animal received all four concentrations of the test material (four test sites per animal). After treatment, all four animals exhibited severe dermal reactions at some of the sites and clinical signs of toxicity. As a result of these observations, the animals were sacrificed in a moribund condition and 24 hour scores were not obtained.
The acute dermal toxicity of the substance in the rat was investigated in a study performed according to OECD TG 402. A limit test was carried out at 2000 mg/kg bw in both sexes. At 5 hours post application, animals were symptom free. However, 24 hours post application, 7 animals were found dead and 3 animals were in a moribund status and euthanized for animal welfare reason. Test item-related black diffuse discoloration of the skin (external examination) and red-black diffuse discoloration of the skin (internal examination) were observed at the sites of application.
Furthermore, the test item belongs to a class of substances that are classified as irritant or even corrosive to skin and/or eyes. Also the pH of the substance is high (pH >13).
Taking into account the overall data available for the substance it is concluded that it has a strongly irritating / corrosive potential to the skin and eye.
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: corrosive
Justification for classification or non-classification
Based on a weight-of-evidence approach the test substance is classified for the endpoint in accordance to the CLP Regulation (EC) No 1272/2008 with skin corrosive category 1C.
Based on a weight-of-evidence approach the test substance is classified for the endpoint in accordance to the CLP Regulation (EC) No 1272/2008 with eye corrosion category 1.
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