Triethyl phosphite

Eye irritation

Administrative data

Endpoint:

eye irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1982

Reliability:

2 (reliable with restrictions)

Data source

Reference

Reference Type:

other: Unpublished report

Title:

Testing for primary irritant / corrosive effect on the skin of rabbits,"

Author:

Suberg H,

Year:

1983

Bibliographic source:

Unpublished report of Bayer AG, May 30, 1983

Report date:

1983

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 405 (Acute Eye Irritation / Corrosion)

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Triethyl phosphite

EC Number:

204-552-5

EC Name:

Triethyl phosphite

Cas Number:

122-52-1

Molecular formula:

C6H15O3P

IUPAC Name:

triethyl phosphite

Test animals / tissue source

Species:

rabbit

Strain:

other: HC:NZW

Test system

Duration of treatment / exposure:

24 h

Observation period (in vivo):

Observations at 1, 24, 48 and 72 hours and at 7 days after instillation of the test substance. Scoring was performed according to the Draize scheme

Number of animals or in vitro replicates:

3

Results and discussion

In vivo

Results

Remarks on result:

other: No effects were noted in corneae and irises at any observation

Other effects:

Result : 1 hour after application: all three animals showed erythema (grade 1 or 2) and two of them also chemiosis (grade 1); 24 hours after application: two animals showed erythema (grade 1) All effects were completely reversible within 48 hours. No effects were noted in corneae and irises at any observation

Applicant's summary and conclusion

Interpretation of results:

slightly irritating

Remarks:

Migrated information

Conclusions:

slightly irritating effects on the eyes .