Registration Dossier
Registration Dossier
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EC number: 208-482-6 | CAS number: 530-48-3
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study according EU/OECD guideline.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- 1,1-diphenylethylene
- EC Number:
- 208-482-6
- EC Name:
- 1,1-diphenylethylene
- Cas Number:
- 530-48-3
- Molecular formula:
- C14H12
- IUPAC Name:
- (1-phenylethenyl)benzene
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 2000 mg/kg body weight (bw)
- No. of animals per sex per dose:
- 5 male-, 5 female rats
- Control animals:
- no
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
Any other information on results incl. tables
There were no mortalities.
Slight to moderate hair loss was noted in all female animals from either Study Day 2 or 3 until Study Day 15. No treatment-related clinical signs of toxicity were observed in male animals.
The mean body weight gain in females was slightly reduced compared to background control data. There was no treatment-related effect on body weight gain in males.
No abnormalities of the thoracic and abdominal viscera were observed.
The acute oral LD50 value of the test substance in both male and female rats was greater than 2000 mg/kg body weight.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- It was concluded that 1, 1 diphenylethylene (AE C512947 PC11631MC), was of low acute oral toxicity to the rat.
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