3-aminopropan-1-ol

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1979

Report date:

1979

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Draize test

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

3-aminopropan-1-ol

EC Number:

205-864-4

Cas Number:

156-87-6

Molecular formula:

C3H9NO

IUPAC Name:

3-aminopropan-1-ol

Test animals

Species:

rabbit

Strain:

Vienna White

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Gaukler
- Weight at study initiation: 3.1 kg

Test system

Type of coverage:

not specified

Preparation of test site:

shaved

Vehicle:

unchanged (no vehicle)

Controls:

other: untreated skin

Amount / concentration applied:

no data

Duration of treatment / exposure:

3 min and 1 hour

Observation period:

8 days

Number of animals:

2 animals (1 male, 1 female)

Details on study design:

no data

Results and discussion

In vivo

Results

Results 1

Irritation parameter:

erythema score

Basis:

animal #1

Time point:

24 h

Score:

4

Max. score:

4

Reversibility:

not reversible

Remarks on result:

other: 1 hour exposure

Results 2

Irritation parameter:

edema score

Basis:

animal #1

Time point:

24 h

Score:

2

Max. score:

4

Reversibility:

not reversible

Remarks on result:

other: 1 hour exposure

Results 3

Irritation parameter:

erythema score

Basis:

animal #1

Time point:

48 h

Score:

4

Max. score:

4

Reversibility:

not reversible

Remarks on result:

other: 1 hour exposure

Results 4

Irritation parameter:

edema score

Basis:

animal #1

Time point:

48 h

Score:

3

Max. score:

4

Reversibility:

not reversible

Remarks on result:

other: 1 hour exposure

Results 5

Irritation parameter:

erythema score

Basis:

animal #1

Time point:

other: 8 d

Score:

4

Max. score:

4

Reversibility:

not reversible

Remarks on result:

other: 1 hour exposure

Results 6

Irritation parameter:

edema score

Basis:

animal #1

Time point:

other: 8 d

Score:

2

Max. score:

4

Reversibility:

not reversible

Remarks on result:

other: 1 hour exposure

Results 7

Irritation parameter:

erythema score

Basis:

animal #1

Time point:

72 h

Remarks on result:

not measured/tested

Results 8

Irritation parameter:

edema score

Basis:

animal #1

Time point:

72 h

Remarks on result:

not measured/tested

Results 9

Irritation parameter:

erythema score

Basis:

animal #2

Time point:

24 h

Score:

4

Max. score:

4

Reversibility:

not reversible

Remarks on result:

other: 1 hour exposure

Results 10

Irritation parameter:

edema score

Basis:

animal #2

Time point:

24 h

Score:

2

Max. score:

4

Reversibility:

not reversible

Remarks on result:

other: 1 hour exposure

Results 11

Irritation parameter:

erythema score

Basis:

animal #2

Time point:

48 h

Score:

4

Max. score:

4

Reversibility:

not reversible

Remarks on result:

other: 1 hour exposure

Results 12

Irritation parameter:

edema score

Basis:

animal #2

Time point:

48 h

Score:

2

Max. score:

4

Reversibility:

not reversible

Remarks on result:

other: 1 hour exposure

Results 13

Irritation parameter:

erythema score

Basis:

animal #2

Time point:

other: 8 d

Score:

4

Max. score:

4

Reversibility:

not reversible

Remarks on result:

other: 1 hour exposure

Results 14

Irritation parameter:

edema score

Basis:

animal #2

Time point:

other: 8 d

Score:

2

Max. score:

4

Reversibility:

not reversible

Remarks on result:

other: 1 hour exposure

Results 15

Irritation parameter:

erythema score

Basis:

animal #2

Time point:

72 h

Remarks on result:

not measured/tested

Results 16

Irritation parameter:

edema score

Basis:

animal #2

Time point:

72 h

Remarks on result:

not measured/tested

Results 17

Irritation parameter:

erythema score

Basis:

mean

Time point:

24/48 h

Score:

4

Max. score:

4

Reversibility:

not reversible

Remarks on result:

other: 1 hour exposure

Results 18

Irritation parameter:

edema score

Basis:

mean

Time point:

24/48 h

Score:

2.25

Max. score:

4

Reversibility:

not reversible

Remarks on result:

other: 1 hour exposure

Any other information on results incl. tables

After 8 days, the erythema and edema score of both animals were 4 and 2 respectively, necrosis was observed in both animals.

A parasitic infestation of the liver was observed in both animals, which was of no relevance for this study.

 Individual readings:

Readings	Animal	Exposure period: 3 min
		Erythema	Edema	Additional findings
3 min	1	2	0
	2	2	0	spotted appearance
24 h	1	2	1
	2	2	1	spotted appearance
48 h	1	2	0
	2	2	1
72 h	1	nd	nd
	2	nd	nd
8 d	1	0	0
	2	1	0	desquamation
Mean 24, 48, 72 h	1	2	0.5
	2	2	1
Mean 24, 48, 72 h	1-2	2	0.75

 

Readings	Animal	Exposure period: 1 hour
		Erythema	Edema	Additional findings
1 h	1	2	2	spotted appearance, exceeding area of application
	2	2	2	spotted appearance, exceeding area of application, soft necrosis
24 h	1	4	2	exceeding area of application, soft necrosis
	2	4	2	exceeding area of application, soft necrosis
48 h	1	4	3	exceeding area of application, parchment-like necrosis
	2	4	2	exceeding area of application, parchment-like necrosis
72 h	1	nd	nd
	2	nd	nd
8 d	1	4	2	exceeding area of application, leather-like necrosis
	2	4	2	leather-like necrosis
Mean 24, 48 h	1	4	2.5
	2	4	2
Mean 24, 48 h	1-2	4	2.25

nd: not determined

Leather-like or hard necroses represent so-called full-thickness necroses involving all layers of the skin. Such necroses are relevant for classification representing a chemical being corrosive to the skin.

Applicant's summary and conclusion

Interpretation of results:

Category 1B (corrosive) based on GHS criteria

Conclusions:

Necrosis was observed in both animals after an exposure period of 1 hour.