Registration Dossier
Registration Dossier
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EC number: 205-864-4 | CAS number: 156-87-6
Endpoint summary
Administrative data
Description of key information
The substance is acutely harmful to aquatic organisms (Skeletonema costatum, 72 -h ErC50 = 21 mg/L, nominal, Eide Haugmo et al. 2009/2012)
Additional information
Acute toxicity to fish
In a BASF study conducted in 1988 the toxicity of the test substance on the Golden orfe was determined. The 96h LC50 was > 1000 mg/L (nominal, pH-adjusted, BASF AG, Rep. no.: 10F0564/875274, 1988). It can be concluded that the substance is with high probability acutely not harmful to fish
Acute toxicity to aquatic invertebrates
As key study a static study was performed similar to OECD 202 using Daphnia magna as test organism (BASF AG, rep. no.: 1/0022/2/89, 1989). In unbuffered test solutions, the 48h EC50 was determined to be >500 mg/L, based on nominal test concentrations. It can be concluded that the substance is with high probability acutely not harmful to aquatic invertebrates.
Toxicity to algae and cyanobacteria
In study conducted according to German standard Guideline DIN 38412/9 (BASF AG, 1989) a 72 -hour ErC50 was determined to be higher than 500 mg/L(nominal, pH-adjusted, BASF AG, Rep. no.:2/0022/89/t72). This study was selected as key study for the freshwater compartment.
In addition, the substance was tested under marine conditions according to ISO 10253 (Eide-Haugmo, 2009/2012), using Skeletonema costatum as test organism. The 72-h ErC50 was determined to be 21.0 mg/L. This study was selected as key study for marine water.
In conclusion, the substance is not acutely harmful to aquatic freshwater algae, but acutely harmful to marinewater algae.
Toxicity to microorganisms
In a short-term respiration test a 30-min EC20 of > 1995 mg/L was determined, using industrial activated sludge as inoculum. Hence, the EC50 is also >1995 mg/L (BASF AG, 1980, rep. no.: 1051/80). Additionally, the substance was tested in a single species test with Pseudomonas putida as test organism (DIN 38412, part 8; ISO 10712). In this test a 17-h EC10 of 96 mg/L was determined (BASF AG, 1987, rep. no.: 9/0789/87). Therefore, it can be concluded, that the inhibition of the degradation activity of activated sludge is not anticipated when introduced in appropriate low concentrations.
The test concentrations were not analytically verified. However, the substance is assumed to be stable due to the substances' water solubility (e.g. see IUCLID Chapter 4.8 ), its low vapor pressure (VP = 0.149 hPa @25°C; BASF AG, 1992) and its low Henry's Law Constant (HLC = 4.95E-05 Pa m³/mol, calculated with the EPI Suite v4.11, BASF SE 2016).
Moreover, it is concluded, that the significant adsorption is not expected for the substance (KOCWIN v2.00, EPISuite v4.11: log Koc = 0.33 (MCI Method), logKoc = -0.13 (Kow method) / Franco&Trapp, log Koc at pH 7 = 1.24, pKa= 10.22, SPARC v4.6)
In conclusion, the substance is acutely harmful to aquatic organisms (Skeletonema costatum, 72 -h ErC50 = 21 mg/L, nominal, Eide Haugmo et al. 2009/2012)
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