Registration Dossier
Registration Dossier
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EC number: 915-035-5 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Skin irritation of chromium(III) oxide was tested by the OECD 404 guideline study. The results showed no signs of irritation.
Eye irritation of chromium(III) oxide was tested by the OECD 405 guideline study, resulting in no irritation.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
No data was available on irritation/corrosion of the reaction mass of heptachromium tricarbide and trichromium dicarbide.
Standard OECD tests showed that chromium(III) oxide is not a skin or eye irritant. The results on skin irritation are also supported by an older non-guideline study. An old study on eye irritation showed slight irritation of the conjunctiva, but the method differs from today's standards (i.e. the test substance was not washed away).
A subchronic rat inhalation study showed only mild inflammatory changes after exposure to chromium(III) oxide, although particle accumulation in the lungs and the peribronchial lymphatic system was evident (see 7.9.3).
The release of chromium from chromium carbide is similar to or lower than the release from chromium metal and chromium(III) oxide. Therefore the substances can be assumed to behave similarly and the results obtained with chromium(III) oxide can be applied to the reaction mass of heptachromium tricarbide and trichromium dicarbide.
Justification for classification or non-classification
No classification is suggested for the reaction mass of heptachromium tricarbide and trichromium dicarbide for irritation/corrosion, based on the results of OECD guideline tests for skin and eye irritation and a repeated dose inhalation study.
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