Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 201-201-8 | CAS number: 79-38-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Additional information
Aquatic toxicity studies are not proposed by the registrant because direct or indirect exposure of the aquatic compartment is unlikely to occur as the substance is a volatile gas with a boiling point in the range of -26.2°C (The Beilstein database. Reference: Miller - 1951 ) to -26.8°C (The Beilstein database. Reference: Henne - 1948) which primarily and rapidly partition the atmosphere where it remains.
The above considerations have been deducted on the following basis:
The Guidance on Information Requirements and Chemical Safety Assessment Chapter R.7a: Endpoint Specific Guidance, Appendix R.7.1-4 indicates that substances with a Henry's Law constant of around 1 hPa m3/mole will rapidly volatilise from water. On the basis of a Henry’s Law constant of 31,500 Pa m3/mol (HENRYWIN v3.20, EPISUITE v1.00), a vapour pressure of 612 kPa at 25°C (ISCS No. 0685, NIOSH) and a moderate water solubility, CTFE is expected to primarily and rapidly partition to the atmosphere.
The value of water solubility of 380 mg/l was experimentally determined in a completely sealed system with an atmosphere saturated with CTFE. Although the value of 380 mg/l itself reveals a moderate water solubility, it represents an overestimation of the actual water solubility of CTFE in the natural system since the experimental conditions did not represent the natural conditions.
The EQC Fugacity III Model (Version 2.02, The Canadian Centre for Environmental Modelling and Chemistry, May 2003)
confirms that all the CTFE released to air remains in this compartment. The model was run assuming emission only to air. In case of an accidental emission, CTFE is only released to atmosphere, because CTFE is a volatile gas at ambient conditions with a boiling point in the range of -26.2°C (The Beilstein database. Reference: Miller - 1951 ) to -26.8°C (The Beilstein database. Reference: Henne - 1948). Therefore, CTFE would not be expected to partition into water.The specific properties of the substance, cited above, indicates the difficulty to properly test CTFE and provide meaningful results of its aquatic toxicity for this reason any experimental aquatic toxicity data are available. However, in order to evaluate the aquatic hazard profile of CTFE despite the fact, that it is expected to rapidly partition to the atmospheric compartment, the ECOSAR model may be applied.
All ECOSAR results are reported in the specific endpoints of this section however, the ECOSAR model cannot be considered reliable for the ECOSAR class of chemicals which CTFE is assigned to, since the results are either based on a very limited dataset of substances or, as for the most sensitive and critical group of the food chain the fish, the coefficient of determination R^2 is low.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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