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EC number: 201-837-6 | CAS number: 88-51-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: publication not sufficient for full methodological assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 992
Materials and methods
Test guideline
- Guideline:
- other: detailed description of methodology not published
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-amino-6-chlorotoluene-3-sulphonic acid
- EC Number:
- 201-837-6
- EC Name:
- 4-amino-6-chlorotoluene-3-sulphonic acid
- Cas Number:
- 88-51-7
- Molecular formula:
- C7H8ClNO3S
- IUPAC Name:
- 2-amino-4-chloro-5-methylbenzene-1-sulfonic acid
- Test material form:
- other: particles suspended in an air stream
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Crl:CD
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- nose only
- Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- gravimetric analsysis at 1/2 hour intervals during each exposure, particle size properties determined during each exposure
- Duration of exposure:
- 4 h
- Remarks on duration:
- single exposure time for each of 3 group
- Concentrations:
- 1. 1st group of 6 rats: range 2.2 - 11 mg/l, mean 4.8 mg/l, standard deviation 3.1 mg/l; particle size 73% respirable, mass median diameter 2.0µ
2. 2nd group of 6 rats: range 1.7 - 21 mg/l, mean 12 mg/l, standard deviation 7.4 mg/l; particle size 45% respirable, mass median diameter 5.0µ
3. 3rd group of 6 rats: range 5 - 18 mg/l, mean 13 mg/l, standard deviation 3.8 mg/l, particle size 60% respirable, mass median diameter 8.3µ
Results and discussion
Effect levels
- Remarks on result:
- other: Lethal concentration not assignable since none of the rats of each group showed a lethal reaction at a concentration of 13 mg/l, the highest possible concentration generated under the experimental conditions
- Mortality:
- none of the rats of each group showed a lethal reaction at a concentration of 13 mg/l, the highest possible mean concentration generated under the experimental conditions
- Body weight:
- slight initial weight loss followed by gain of weight
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: other: Interpretation of literature data
- Conclusions:
- The NOAEL of 13 mg/l is above the threshold for classification according to Regulation (EC) no. 1272/2008, Directive 67/548/EEC respectively. Hence the substance is not needed to be classified.
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