Registration Dossier

Administrative data

Endpoint:
short-term toxicity to fish
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Study period:
1988
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
Read-across from the structural isomer 5-Amino-2-chlorotoluene-4-sulphonic acid (CLT-acid)n CAS 88-53-9 in which the positions of chlorine and methyl are exchanged Read-across from supporting substance (structural analogues of category ¿quinacridone pigments¿) Source: Pigment Red 282 (909-082-0)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1988
Report Date:
1989

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
OECD Guideline 203 (Fish, Acute Toxicity Test)
Qualifier:
according to
Guideline:
EU Method C.1 (Acute Toxicity for Fish)
GLP compliance:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test solutions

Vehicle:
no
Details on test solutions:
aqueous solution of test substance with small precipitation amounts

Test organisms

Test organisms (species):
Danio rerio (previous name: Brachydanio rerio)

Study design

Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
96 h

Test conditions

Test temperature:
21.3 - 22-4 °C
pH:
6.2 - 8.1
Dissolved oxygen:
6.4 - 9.1 mg/l
Nominal and measured concentrations:
Nominal concentrations: 1 000, 3 500, 5 000, 7 100 and 10 000 mg/L.
Reference substance (positive control):
no

Results and discussion

Effect concentrationsopen allclose all
Duration:
96 h
Dose descriptor:
LC0
Effect conc.:
3 500 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
6 350 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Duration:
96 h
Dose descriptor:
LC100
Effect conc.:
10 000 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality

Any other information on results incl. tables

Justification for CLT-acid as a read across substance for the short-term fish toxicity of 2B-acid:

The read across substance CLT-acid (CAS-no. 88 -53 -9) differs from the registered substance 2B-acid (CAS-no. 88 -51 -7) only by the exchanged positions of the methyl and the clorine substituents. All other structural elements and positions are identical.

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
67/548/EEC: Acute aquatic toxicity: no classification
1272/2008/EC: Acute aquatic toxicity: no classification