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EC number: 253-760-2 | CAS number: 38051-10-4
In vitro plate incorporation assay, bacteria (Ames)
Safepharm Labs Ltd. 1993
Mammalian cell gene mutation (L5178Y TK+/-cells)
Mobil Environ. & Health Sci. Lab. 1983
Induction of chromosome aberrations (Human lymphocytes)
Safepharm Labs Ltd. 1994
In vivo Mouse Micronucleus assay
Short description of key information:
The substance was not genotoxic in standard in vitro genotoxicity studies in bacterial (S. typhimurium TA1535, TA1537, TA98, TA100, TA102) and mammalian cells (mouse lymphoma L15178Y TK+/- cells, a chromosomal aberration study in mammalian cells (human lymphocytes)) with and without metabolic activation. In an in vivo mouse micronucleus test the substance was not clastogenic.
Endpoint Conclusion: No adverse effect observed (negative)
In vitro and in vivo genotoxicity tests performed with the test substance did all not indicate a possible mutagenic or genotoxic effect. Therefore the substance should not be classified for mutagenicity according to regulation (EC) 1272/2008 and EC Dir. 67/548 and adaptations.
European Union Risk Assessment Report "2,2-Bis(chloromethyl)trimethylene bis[bis(2-chloroethyl)phophate]" (V6), CAS 38051-10-4, May 2008
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