Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 253-760-2 | CAS number: 38051-10-4
In short-term oral repeated dose toxicity study, 2,2-bis(chloromethyl)trimethylene bis(bis(2-chloroethyl)phosphate) was administered to 20 male and 20 female Sprague-Dawley rats by gavage at dose levels of 0, 15, 150 and 600 mg/kg bw/day.
There were no compound related effects in mortality, clinical signs, body weight, food consumption and hematology. At 150 mg/kg/day significantly increased liver weight and slight centrilobular hepatocellular hypertrophy was noted among female animals. At 600 mg/kg/day significant liver weight increase, liver enlargement, centrilobular hepatocellular hypertrophy without evidence of nuclear or cytoplasmic degenerative or necrotic changes, and morphological changes indicative of thyroid hyperactivity as well as an increase in blood cholesterol levels were noted in male and female animals. As the effects in the mid dose can also be regarded as adaptive changes due to liver enzyme induction, rather than adverse, the NOAEL is considered conservative.
The NOAEL under the experimental conditions of this study is 15 mg/kg/day.
This repeated dose study in the rat is acceptable and satisfies the guideline requirement for a 28 -day repeated dose oral toxicity study in rodents, according to OECD Guideline No.407.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again