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EC number: 253-760-2 | CAS number: 38051-10-4
- Dermal delivery (sum of the absorbed dose and amount in skin) of the test substance was 0.51% +- 0.5 (72.04 microg equiv./cm2) and 6.10% (12.78 microg equiv./cm2) for the test substance in ethanol
- Steady state flux was achieved for the neat test substance from 14 -24h, and from 2 -5h for the test substance in ethanol
- The mass balance was complete for the test substance (105.03%) and the test substance in ethanol (98.57%).
- The majority of the dose was not aborbed and could be removed by washing.
In an in vitro skin absorption study 8 human skin samples were treated with radiolabelled 2,2 -bis(chloromethyl)trimethylene bis(bis(2 -chloroethyl)phosphate) either undiluted or at a concentration of 20.96 g/L in ethanol at application rates of 14.03 mg equiv./cm2 and 0.210 mg equiv./cm2 respectively for 8h under open condittions. Sampling continued after washing at 8h until 24 hours after dosing.
Dermal delivery of the test substance was 0.51% (72.04 microg equiv./cm2) and 6.10% (12.78 microg equiv./cm2) for the test substance in ethanol.
The absorbed dose of the test substance was 0.19% (26.95 microg equiv/cm2), and 2.19% for the test substance in ethanol (4.60 microg equiv/cm2).
This study is classified as valid without restrictions and is conducted in accordance with GLP regulations and OECD Guideline No.428 and OECD Guidance document No.28.
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