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Diss Factsheets
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EC number: 236-751-8 | CAS number: 13473-90-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian germ cell study: cytogenicity / chromosome aberration
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Study period:
- Not relevant
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Limited experimental data are presented in this published study
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- Effects of aluminium salts on bone marrow chromosomes in rats in vivo
- Author:
- Roy AK, Talukder G & Sharma A
- Year:
- 1 991
- Bibliographic source:
- Cytobios. 66 (1991) 105-111
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The effects of Aluminium sulphate (Aluminium Sulphate 18 H20) was tested on bone marrow chromosomes in rats in vivo at six dose levels: 2.120, 1.060, 530, 353, 265, and 212 mg/kg/bw. For each concentration, fifteen animals were used and five animals were sacrificed at the end of each week. 3 sampling times occurred at 7, 14 and 21 days. Bone marrow chromosomes were prepared by the standard protocol. From each animal, 2,000 cells were scored for the mitotic index and 60 well scattered metaphase plates for chromosomal aberration, making a total of 10,000 cells and 300 metaphases per set, respectively. For the calculation of breaks/cell, chromatid breaks were taken as a single break, dicentrics and translocations as two breaks.
- GLP compliance:
- not specified
- Type of assay:
- chromosome aberration assay
Test material
- Reference substance name:
- aluminium sulphate 18 H2O
- IUPAC Name:
- aluminium sulphate 18 H2O
- Test material form:
- not specified
- Details on test material:
- No information available
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No information
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- No information
- Details on exposure:
- The effects of Aluminium sulphate (Aluminium Sulphate 18 H20) was tested on bone marrow chromosomes in rats in vivo dosed orally at six dose levels: 2.120, 1.060, 530, 353, 265, and 212 mg/kg/bw. For each concentration, fifteen animals were used and five animals were sacrificed at the end of each week. 3 sampling times occurred at 7, 14 and 21 days.
- Duration of treatment / exposure:
- Five animals were sacrificed at the end of each week. 3 sampling times occurred at 7, 14 and 21 days.
- Frequency of treatment:
- daily
- Post exposure period:
- five animals were sacrificed at the end of each week. 3 sampling times occurred at 7, 14 and 21 days.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
2.120, 1.060, 530, 353, 265, and 212 mg/kg/bw.
Basis:
- No. of animals per sex per dose:
- 15 per group
- Control animals:
- not specified
- Positive control(s):
- No data
Examinations
- Tissues and cell types examined:
- For each concentration, fifteen animals were used and five animals were sacrificed at the end of each week. 3 sampling times occurred at 7, 14 and 21 days. Bone marrow chromosomes were prepared by the standard protocol. From each animal, 2,000 cells were scored for the mitotic index and 60 well scattered metaphase plates for chromosomal aberration, making a total of 10,000 cells and 300 metaphases per set, respectively. For the calculation of breaks/cell, chromatid breaks were taken as a single break, dicentrics and translocations as two breaks.
- Details of tissue and slide preparation:
- For each concentration, fifteen animals were used and five animals were sacrificed at the end of each week. 3 sampling times occurred at 7, 14 and 21 days. Bone marrow chromosomes were prepared by the standard protocol. From each animal, 2,000 cells were scored for the mitotic index and 60 well scattered metaphase plates for chromosomal aberration, making a total of 10,000 cells and 300 metaphases per set, respectively. For the calculation of breaks/cell, chromatid breaks were taken as a single break, dicentrics and translocations as two breaks.
- Evaluation criteria:
- No information given in publication
- Statistics:
- No data
Results and discussion
Test results
- Sex:
- not specified
- Genotoxicity:
- positive
- Toxicity:
- not specified
- Vehicle controls validity:
- not specified
- Negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Additional information on results:
- Oral administration of Aluminium sulphate to rats for prolonged periods induced dose dependent inhibition of dividing cells and an increase in chromosomal aberrations. The effect was not influenced by the duration of exposure
Any other information on results incl. tables
Bone marrow chromosomes were prepared by the standard protocol. From each animal, 2,000 cells were scored for the mitotic index and 60 well scattered metaphase plates for chromosomal aberration, making a total of 10,000 cells and 300 metaphases per set, respectively. For the calculation of breaks/cell, chromatid breaks were taken as a single break, dicentrics and translocations as two breaks.
Oral administration of Aluminium sulphate to rats for prolonged periods induced dose dependent inhibition of dividing cells and an increase in chromosomal aberrations. The effect was not influenced by the duration of exposure.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): ambiguous
Oral administration of Aluminium sulphate to rats for prolonged periods induced dose dependent inhibition of dividing cells and an increase in chromosomal aberrations. The effect was not influenced by the duration of exposure. - Executive summary:
The effects of Aluminium sulphate (Aluminium Sulphate 18 H20) was tested on bone marrow chromosomes in rats in vivo at six dose levels: 2.120, 1.060, 530, 353, 265, and 212 mg/kg/bw. For each concentration, fifteen animals were used and five animals were sacrificed at the end of each week. 3 sampling times occurred at 7, 14 and 21 days. Bone marrow chromosomes were prepared by the standard protocol. From each animal, 2,000 cells were scored for the mitotic index and 60 well scattered metaphase plates for chromosomal aberration, making a total of 10,000 cells and 300 metaphases per set, respectively. For the calculation of breaks/cell, chromatid breaks were taken as a single break, dicentrics and translocations as two breaks.
Oral administration of Aluminium sulphate to rats for prolonged periods induced dose dependent inhibition of dividing cells and an increase in chromosomal aberrations. The effect was not influenced by the duration of exposure.
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