Registration Dossier
Registration Dossier
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EC number: 416-250-2 | CAS number: 84632-59-7
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
No bioaccumulation hazard is expected based on results of subabacute oral toxicity data in rats, because of physico-chemical properties and the results of a fish feeding study. Absence of uptake after oral dosing of a related pigment was observed.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
Experimental data indicates absence of systemic availability as no efffects were observed in any toxicity study, including the subacute oral toxicity study and the screening study for reproductive toxicity. This is typical for organic pigments that are neither sufficiently soluble in water or octanol for transport via biological membranes. Also for this pigment, a fish feeding study is available showing absence of uptake.
For the analogue diketopyrrolopyrrol Pigment (Pigment Red 254, CAS 84632-65-5) a toxikokinetic study in rats is available and no significant uptake of the pigment after gavage dosing was observed. Pigment Red 254 differs from Pigment Orange 73 in that the tertiary butyl groups are chlorine. Considering general chemistry knowledge, this substution does not alter solubility properties. The bulkyness and molecular size of the chlorinated pigment will be slightly less and therefore in theory more favourable for uptake. Therefore, toxicokinetic data of Pigment Red 254 is acceptable for use on Pigment Orange 73.
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