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EC number: 203-585-2 | CAS number: 108-46-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Remarks:
- in vivo antithyroid activity in rats
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: No additional details available. Included due to prior inclusion in SIAR.
Data source
Reference
- Reference Type:
- publication
- Title:
- Humic substances, a possible source of environmental goitrogens.
- Author:
- Cooksey, R.C., Gaitan, E., Lindsay, R.F., Hill, H.B., Kelly, K.
- Year:
- 1 985
- Bibliographic source:
- Organic Geochemistry 8:77-80.
Materials and methods
- Type of study / information:
- Type: other: In vivo, antithyroid activity
Test guideline
- Qualifier:
- no guideline required
Test material
- Reference substance name:
- Resorcinol
- EC Number:
- 203-585-2
- EC Name:
- Resorcinol
- Cas Number:
- 108-46-3
- Molecular formula:
- C6H6O2
- IUPAC Name:
- resorcinol
Constituent 1
Results and discussion
Any other information on results incl. tables
Resorcinol exhibited goitrogenic as well as antithyroid effects in vivo in the rat. When compared with the controls, resorcinol treated rats had significantly larger thyroid glands and decreased the ability of their thyroids to incorporate 125I into the active thyroid hormones, triiodothyronine (T3) and thyroxine (T4) as indicated by higher I/T3and T4 ratio and lower T3and T4 concentrations.
Applicant's summary and conclusion
- Conclusions:
- Female rats of Wistar Crl:(WI) BR strain weighing 95-105 g were divided into groups of 5 rats each and fed on a low iodine low protein shredded wheat diet for the duration of the experiment, lasting 30 days. Control rats were given goitrogen-free water while experimental rats received daily 9 umol of resorcinol in their water.
Resorcinol exhibited goitrogenic as well as antithyroid effects in vivo in the rat. When compared with the controls, resorcinol treated rats had significantly larger thyroid glands and decreased the ability of their thyroids to incorporate 125I into the active thyroid hormones, triiodothyronine (T3) and thyroxine (T4) as indicated by higher I/T3and T4 ratio and lower T3and T4 concentrations.
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