Registration Dossier

Administrative data

Endpoint:
short-term repeated dose toxicity: dermal
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
other:
Justification for type of information:
1-methyl piperazine is corrosive to skin Category 1B, it is also a skin sensitiser, therefore dermal exposure will be avoided by the use of appropriate personal protection and mechanised handling. It is not justified scientifically and from animal welfare considerations to do a repeat dose dermal toxicity study as 1-methyl piperazine is corrosive to skin. ECHA Guidance allow the calculation of dermal DNELs based on oral NOAELs, which is a conservative approach.

Data source

Materials and methods

Results and discussion

Applicant's summary and conclusion