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Toxicological information

Repeated dose toxicity: inhalation

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Administrative data

Endpoint:
repeated dose toxicity: inhalation, other
Remarks:
other: 5 day repeated inhalation test
Type of information:
experimental study
Adequacy of study:
other information
Study period:
1964
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: No analytical monitoring; significant methodological deficiencies

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1964
Report Date:
1964

Materials and methods

Principles of method if other than guideline:
see Test Conditions
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid

Test animals

Species:
other: 20 mice, 10 rats, 2 guinea pigs, 1 rabbit, 1 cat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
whole body
Vehicle:
other: unchanged (no vehicle)
Details on inhalation exposure:
Animals were exposed in a 400 l room to the vapours of the test substance that were generated by heating 20 g of test substance at 160 °C.
The average loss of test substance during the daily exposure was 11.4 g.
Analytical verification of doses or concentrations:
no
Duration of treatment / exposure:
5 days
Frequency of treatment:
4 hours/day
No. of animals per sex per dose:
20 mice, 10 rats, 2 guinea pigs, 1 rabbit, 1 cat (sex not reported)
Control animals:
no
Details on study design:
Post-exposure period: 14 days
Positive control:
none

Examinations

Observations and examinations performed and frequency:
no details reported
Sacrifice and pathology:
no data
Statistics:
no data

Results and discussion

Results of examinations

Clinical signs:
effects observed, treatment-related
Mortality:
mortality observed, treatment-related
Body weight and weight changes:
not examined
Food consumption and compound intake (if feeding study):
not examined
Food efficiency:
not examined
Water consumption and compound intake (if drinking water study):
not examined
Ophthalmological findings:
not examined
Haematological findings:
not examined
Clinical biochemistry findings:
not examined
Urinalysis findings:
not examined
Behaviour (functional findings):
not specified
Organ weight findings including organ / body weight ratios:
not examined
Gross pathological findings:
not examined
Histopathological findings: non-neoplastic:
not examined
Histopathological findings: neoplastic:
not examined
Details on results:
Except for minor signs of irritancy of the mucosa of nose, throat, and eyes, no signs of intoxication were observed.

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion