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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1964
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: limited documentation

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1964
Report Date:
1964

Materials and methods

Principles of method if other than guideline:
see Test Conditions
GLP compliance:
no
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
other: aqueous tragacanth suspension
Details on exposure:
- Doses per time period: single dose
- Volume administered or concentration: 0.5 / 1 / 2.5 / 5 / 6 / 7.5 / 10 %
- Post dose observation period: 7 days
Doses:
50 / 100 / 250 / 500 / 600 / 750 / 1000 mg/kg bw
No. of animals per sex per dose:
10 (total)
Control animals:
not specified
Statistics:
Litchfield and Wilcoxon

Results and discussion

Effect levels
Dose descriptor:
LD50
Effect level:
410 mg/kg bw
Mortality:
- Time of death: within 24 hours
- Number of deaths at each dose:
50 mg/kg: 0
100 mg/kg: 2
250 mg/kg: 2
500 mg/kg: 5
600 mg/kg: 7
750 mg/kg: 9
1000 mg/kg: 10
Clinical signs:
(similar to) impairment of breathing, slight muscle tremor, sedative effects, reduced general condition, beginning 1/2 hour after dosing and reversible within 24 hours, observed in all dose levels except lowest
Body weight:
no data
Gross pathology:
no data

Applicant's summary and conclusion