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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Study period:
1964
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: methodological deficiencies: no analytical monitoring

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1964
Report Date:
1964

Materials and methods

Principles of method if other than guideline:
see Test Conditions
GLP compliance:
no
Test type:
other: LC0
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid

Test animals

Species:
other: 20 mice, 10 rats, 2 guinea pigs, 1 rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
whole body
Vehicle:
other: unchanged (no vehicle)
Details on inhalation exposure:
- Animals were exposed in a 400 l room to the vapors of the test substance that were generated by heating as follows:
Test 1: 10 g heated at 170 °C for 4 hours; loss 9.6 g
Test 2: 40 g heated at 180 °C for 4 hours; loss 15.1 g
Test 3: 40 g heated at 200 °C for 5 hours; loss 26.4 g
- Post exposure observation period: 14 days
Analytical verification of test atmosphere concentrations:
no
Concentrations:
quantification not possible
Control animals:
no

Results and discussion

Mortality:
None
Clinical signs:
Except for minor signs of irritancy of the mucosa of nose, throat, and eyes, no signs of intoxication were observed.
Body weight:
no data
Gross pathology:
no data

Applicant's summary and conclusion