Registration Dossier
Registration Dossier
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EC number: 213-424-8 | CAS number: 947-04-6
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1964
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: methodological deficiencies: no analytical monitoring
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 964
- Report date:
- 1964
Materials and methods
- Principles of method if other than guideline:
- see Test Conditions
- GLP compliance:
- no
- Test type:
- other: LC0
- Limit test:
- yes
Test material
- Reference substance name:
- Dodecane-12-lactam
- EC Number:
- 213-424-8
- EC Name:
- Dodecane-12-lactam
- Cas Number:
- 947-04-6
- Molecular formula:
- C12H23NO
- IUPAC Name:
- 1-azacyclotridecan-2-one
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- other: 20 mice, 10 rats, 2 guinea pigs, 1 rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- - Animals were exposed in a 400 l room to the vapors of the test substance that were generated by heating as follows:
Test 1: 10 g heated at 170 °C for 4 hours; loss 9.6 g
Test 2: 40 g heated at 180 °C for 4 hours; loss 15.1 g
Test 3: 40 g heated at 200 °C for 5 hours; loss 26.4 g
- Post exposure observation period: 14 days - Analytical verification of test atmosphere concentrations:
- no
- Concentrations:
- quantification not possible
- Control animals:
- no
Results and discussion
- Mortality:
- None
- Clinical signs:
- other: Except for minor signs of irritancy of the mucosa of nose, throat, and eyes, no signs of intoxication were observed.
- Body weight:
- no data
- Gross pathology:
- no data
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
