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Administrative data

Link to relevant study record(s)

Description of key information

see "Additional information"

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential

Additional information

Renal excretion of lauryl lactam could be demonstrated in a follow up study of the 90 day oral repeated dose toxicity study (SANOFI, 1993). Urine samples (5 ml/animal) were collected from 5 animals/sex/group on days 45 and 85 from the rats 90 day oral repeated dose toxicity study (Arkema, 2009) and quantification of lauryl lactam via gas chromatography-flame ionization detector was performed in urine samples on 5 males and 4 females of the highest dose group (125 mg/kg/day; Arkema, 2009). Lauryl lactam could be detected in these examined urine samples. There is no further information available on toxicokinetics, metabolism or distribution of lauryl lactam.

The structurally related compound ε-caprolactam was examined regarding toxicokinetics in male, female and pregnant female mice (Waddell et al., 1984).

After oral or i.v. administration of radioactive labelled ε-caprolactam the substance was rapidly absorbed and distributed throughout the animals including the foetuses. There was no retention of radioactivity observed in foetuses.
No differences in pattern of distribution among male, non-pregnant and pregnant mice could be detected. The substance
ε-caprolactam is rapidly eliminated by renal and hepatic routes. Metabolism in liver prior to secretion into bile seems likely.There are indications that enterohepatic circulation is absent. Because of structural similarities between ε-caprolactam and lauryl lactam it is assumed that lauryl lactam shows similar toxicokinetic behaviour.