Registration Dossier
Registration Dossier
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EC number: 202-425-9 | CAS number: 95-50-1
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- sub-chronic toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: original reference not translated (Russian)
Data source
Reference
- Title:
- No information
- Author:
- Burlaka-Vovk, Z.I. et al.: in Endocrine system and toxic|environmental factors. Leningrad; 1979: 19-24: cited in|Chlorobenzenes (Series "Scientific Reviews of Soviet Lit-|erature of Toxicity and Hazards of Chemicals"), edited by |Izmerov, N.F., Centre for International Projects, GKNT, |Moscow, 1988; data compiled by Vasilenko, N.M. and Semilet-|kina, N.N. (number of issue: 108)
Materials and methods
- GLP compliance:
- no
Test material
- Reference substance name:
- 1,2-dichlorobenzene
- EC Number:
- 202-425-9
- EC Name:
- 1,2-dichlorobenzene
- Cas Number:
- 95-50-1
- Molecular formula:
- C6H4Cl2
- IUPAC Name:
- 1,2-dichlorobenzene
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation
- Duration of treatment / exposure:
- 7-8 months
- Frequency of treatment:
- 4 h/d, 5 d/w
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.05 mg/l
Basis:
- Control animals:
- yes
- Details on study design:
- Post-exposure period: no data
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Effects on adrenal cortex function: short increase in the blood plasma level of 11-oxycorticosteroids at 3 and 5 months of exposure.
Applicant's summary and conclusion
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