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EC number: 202-425-9 | CAS number: 95-50-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
ORAL EXPOSURE:
A single dose oral toxicity study of 1,2-dichlorobenzene was conducted
according to OECD guideline 401 (Nagata et al., 2001). The LD50 values
were estimated to be greater than 2000 mg/kg for males and females.
Older studies found lower LD50 values. According to the harmonised
classification - Annex VI of Regulation (EC) No 1272/2008 (CLP
regulation) 1,2-dichlorobenzene is classified as Acute Tox. 4* (H302:
Harmful if swallowed).
INHALATIVE EXPOSURE
There are several limited acute inhalation toxicity studies available.
Based on a weight-of-evidence approach and according to CLP
classification criteria (Regulation (EC) No 1272/2008) a classification
as Acute Tox 4 ( H332: Harmful if inhaled.) is proposed.
DERMAL EXPOSURE
No data available
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Quality of whole database:
- A single dose oral toxicity study of 1,2-dichlorobenzene was conducted according to OECD guideline 401 (Nagata et al., 2001). The LD50 values were estimated to be greater than 2000 mg/kg for males and females. Older studies found lower LD50 values. According to the harmonised classification - Annex VI of Regulation (EC) No 1272/2008 (CLP regulation) 1,2-dichlorobenzene is classified as Acute Tox. 4* (H302: Harmful if swallowed).
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Quality of whole database:
- There are several limited acute inhalation toxicity studies available. Based on a weight-of-evidence approach and according to CLP classification criteria (Regulation (EC) No 1272/2008) a classification as Acute Tox 4 ( H332: Harmful if inhaled.) is proposed.
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
ORAL EXPOSURE:
Nagata et al., 2001
A single dose oral toxicity study of 1,2-dichlorobenzene was conducted according to OECD guideline 401. The GLP study was considered to be reliable because no deviations were mentioned.
Male Crj: CD(SD) rats were dosed with 0 (vehicle only), 500, 1000, or 2000 mg/kg bw of 1,2-dichlorobenzene. In addition, female Crj: CD(SD) rats were administered 2000 mg/kg bw in order to show that there were no gender-specific differences. According to guideline 5 animals per dose group and sex were used.
Deaths occurred of male rats given 2000 mg/kg bw. Clinical signs of decrease in locomotor activity, adoption of a prone position, tremors, irregular respiration and salivation were observed. Body weights of the treated animals were dose dependently lower than those of the control group. At autopsy, pale discoloration of the liver and accumulation of dark colored fluid in the urinary bladder were observed in dead animals. Histopathologically, the liver showed degeneration and /or necrosis of hepatocytes accentuated in the centrilobular area in dead animals and centrilobular hypertrophy of hepatocytes in a survivors.
The LD50 values were estimated to be greater than 2000 mg/kg for males and females. Hence, the test requires no classification according to EU-GHS.
INHALATIVE EXPOSURE (weight of evidence approach):
Bonnet, 1982
An acute toxicity study had been conducted on male rats. The reliability is not assignable because the publication is not translated. The LC50 was determined by inhalative exposure of male SD rats for 6 h. The concentrations (1383-1730 ppm) of the vaporised 1,2-dichlorobenzene were analysed regularly. A LC50 of 1532 ppm (9.36 mg/L) was stated. After conversion, the LC50 for 4h was 14.04 mg/L (2298 ppm), which results in an EU-GHS classification "Toxicity Category IV".
Bonnet, 1979
An acute toxicity study had been conducted on female mice. The reliability is not assignable because the publication is not translated. The LC50 was determined by inhalative exposure of female OF1 mice for 6 h. The concentrations (1201 - 1279 ppm) of the vaporised 1,2-dichlorobenzene were analysed regularly. A LC50 of 1236 ppm (7.55 mg/L) was stated. After conversion, the LC50 for 4h was 1854 ppm which results in an EU-GHS classification "Toxicity Category IV".
Justification for classification or non-classification
Acute oral toxicity: According to the harmonised classification - Annex VI of Regulation (EC) No 1272/2008 (CLP regulation) 1,2-dichlorobenzene is classified as Acute Tox. 4* (H302: Harmful if swallowed).
Acute inhalation toxicity: Due to a weight of evidence consideration of the results of the acute inhalation studies, and according to CLP classification criteria (Regulation (EC) No 1272/2008) a classification as Acute Tox 4 ( H332: Harmful if inhaled.) is proposed.
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