Registration Dossier
Registration Dossier
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EC number: 202-425-9 | CAS number: 95-50-1
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Does not meet important criteria of today standard methods (no excreta sampling, blood sampling only at the end of the study, skin from application site not sampled, application area too small, exposure period too short)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 427 (Skin Absorption: In Vivo Method)
- Deviations:
- yes
- Remarks:
- ; no excreta sampling, blood sampling only at the end of the study, skin from application site not sampled, application area too small, exposure period too short
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1,2-dichlorobenzene
- EC Number:
- 202-425-9
- EC Name:
- 1,2-dichlorobenzene
- Cas Number:
- 95-50-1
- Molecular formula:
- C6H4Cl2
- IUPAC Name:
- 1,2-dichlorobenzene
- Details on test material:
- Endpoint study record was created to contribute to teh overall remarks.
Constituent 1
Test animals
- Species:
- rat
- Details on test animals or test system and environmental conditions:
- Endpoint study record was created to contribute to teh overall remarks.
Administration / exposure
- Duration of exposure:
- Endpoint study record was created to contribute to the overall remarks.
- Doses:
- Endpoint study record was created to contribute to the overall remarks.
- No. of animals per group:
- Endpoint study record was created to contribute to the overall remarks.
- Details on study design:
- Endpoint study record was created to contribute to teh overall remarks.
- Details on in vitro test system (if applicable):
- Endpoint study record was created to contribute to teh overall remarks.
Results and discussion
- Absorption in different matrices:
- Endpoint study record was created to contribute to teh overall remarks.
- Total recovery:
- Endpoint study record was created to contribute to teh overall remarks.
- Conversion factor human vs. animal skin:
- Endpoint study record was created to contribute to teh overall remarks.
Any other information on results incl. tables
Blood concentration increased quickly to a max. at 45min; minimal inflammation at 1h
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
