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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: GLP study.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1984

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Single 24 hours application of 0.1 mg dry technical grade chemical to one eye of each of 6 rabbits.
3 additional rabbits had the chemical washed out after a 20 second exposure.
GLP compliance:
yes
Remarks:
no data available

Test material

Constituent 1
Reference substance name:
Mononitroso-RDX
IUPAC Name:
Mononitroso-RDX
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder
Details on test material:
- Name of test material (as cited in study report): Mononitroso-RDX
- Molecular formula (if other than submission substance): C3H6N6O5
- Molecular weight (if other than submission substance): 206
- Substance type: organic
- Physical state: powder
- Analytical purity: no data

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
No data available.

Test system

Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 mg dry techical grade.

VEHICLE
No data
Duration of treatment / exposure:
24 hours
Observation period (in vivo):
No data
Number of animals or in vitro replicates:
9 rabbits
Details on study design:
REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes on three rabbits
- Time after start of exposure: 20 second

SCORING SYSTEM
No data

TOOL USED TO ASSESS SCORE
No data

Results and discussion

In vivo

Results
Remarks on result:
no indication of irritation

Any other information on results incl. tables

Mononitroso-RDX did not cause irritation to the eyes of rabbits under either unwashed or washed conditions.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: not specified
Conclusions:
Irritation to human eyes is not expected from an accidental exposure.