Registration Dossier
Registration Dossier
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EC number: 204-500-1 | CAS number: 121-82-4
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP study.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 984
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Single 24 hours application to intact and abraded skin.
Dry technical grade chemical, 0.5 mg applied to each of 6 rabbits.
Occlusive covering. - GLP compliance:
- yes
Test material
- Reference substance name:
- Mononitroso-RDX
- IUPAC Name:
- Mononitroso-RDX
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): Mononitroso-RDX
- Molecular formula (if other than submission substance): C3H6N6O5
- Molecular weight (if other than submission substance): 206
- Substance type: organic
- Physical state: powder
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available.
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: intact and abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mg.
VEHICLE
No data - Duration of treatment / exposure:
- 24 hours
- Observation period:
- No data available.
- Number of animals:
- 6 rabbits.
- Details on study design:
- No data available.
Results and discussion
In vivo
Results
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- ca. 0
- Max. score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Remarks:
- no information about time points assessed
- Irritant / corrosive response data:
- Chemical exhibits no potential for acute skin irritation and should be considered a non-irritating skin material.
- Other effects:
- No data available.
Any other information on results incl. tables
Mononitroso-RDX did not cause any irritation of the intact or abraded skin.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: not specified
- Conclusions:
- Mononitroso-RDX exhibits no potential for acute skin irritation and should be considered a non-irritating skin material.
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