Registration Dossier

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Comparable to guideline study with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1984
Report date:
1984

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
yes
GLP compliance:
no
Test type:
standard acute method

Test material

Constituent 1
Reference substance name:
Sulfuric acid, mono-C12-13-alkyl esters, sodium salts
EC Number:
295-101-1
EC Name:
Sulfuric acid, mono-C12-13-alkyl esters, sodium salts
Cas Number:
91783-23-2
IUPAC Name:
91783-23-2
Details on test material:
- Name of test material (as cited in study report): trade name
- Physical state: no data
- Analytical purity: 26.76%
- Lot/batch No.: no data

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Doses:
880, 1040, 1260 and 1500 mg/kg bw
No. of animals per sex per dose:
5
Control animals:
no

Results and discussion

Effect levelsopen allclose all
Sex:
male
Dose descriptor:
LD50
Effect level:
1 230 mg/kg bw
Sex:
female
Dose descriptor:
LD50
Effect level:
1 063 mg/kg bw
Mortality:
Male rats:
at 880, 1040mg/kg bw: no mortalities 0/5
at 1260 mg/kg bw: 3/5 animals died within 14 days
at 1500 mg/kg bw: 5/5 animals died within 14 days

Female rats:
at 880 mg/kg bw: no mortalities 0/5
at 1040 mg/kg bw: 2/5 animals died within 14 days
at 1260 mg/kg bw: 5/5 animals died within 14 days
at 1500 mg/kg bw: 5/5 animals died within 14 days
Clinical signs:
not stated
Body weight:
not stated
Gross pathology:
not stated

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Classification:
DSD: Xn, R22 Harmful if swallowed
GHS: Acute Oral Category 4