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Ecotoxicological information

Long-term toxicity to aquatic invertebrates

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Link to relevant study record(s)

Description of key information

The 21 day-EC10 of the structurally related substance ortho-Toluenediamine, propoxylated in a OECD 211 guideline study is 2.5 mg/l (nominal) related to the endpoint reproduction (Bayer Industry Services, 2005)

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Dose descriptor:
EC10
Remarks:
(reproduction)
Effect concentration:
2.5 mg/L

Additional information

Long term toxicity to aquatic invertebrates is addressed via a read across approach. The 21 day-EC10 of the structurally related substance ortho-Toluenediamine, propoxylated in a OECD 211 guideline study is 2.5 mg/l (nominal) for reproduction.
For details and justification of this read-across, please see information provided in the corresponding Endpoint Study record under 6.1.4. The document follows the requirements of the Read-Across Assessment Framework (RAAF, European Chemicals Agency, 2017) and addresses general (dis-) similarities of the two UVCB substances, manufacturing processes, structural similarity, consistency in endpoints measured for both items, impact of different degrees of alkoxylation, degradation of the parent compound(s) and the potential formation of degradation products, bioaccumulation and common underlying mechanisms.