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Short-term toxicity to fish

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Description of key information

The substance is not acutely toxic to fish in the range of solubility.

Key value for chemical safety assessment

Additional information

Whole substance (CAS 192268 -65 -8)

A study conducted according to OECD guideline 203 with the uvcb substance is available (RCC Umweltchemie AG, 1997). A water accommodated fraction was prepared for the investigation. Zebra fish were used as test organisms and the LC50 after 96 hours of semi-static exposure was determined to be > saturation concentration (undiluted filtrate of a nominal loading rate of 100 mg/L). No effects were observed up to highest tested concentration and saturation concentration, respectively.

Structure A (CAS 597 -82 -0)

Two studies on the acute toxicity to fish are available.

In the most recent study (RCC 2002) which was performed according to GLP, zebra-fish (Brachydanio rerio) were exposed for 96-h to the test item at concentrations of 0 (control, solvent control) and saturation concentration (undiluted filtrate with a nominal loading rate of 100 mg/L) under static conditions. The 96-h LC50 was higher than the saturation concentration. The NOECs, based on mortality and sublethal effects, were ≥ the saturation concentration, respectively. Sublethal effects were not observed.

In addition, the 96-h acute toxicity to zebra-fish (Brachydanio rerio) was determined in a supportive non-GLP study (Ciba-Geigy, 1988). In this study test organisms were exposed to test item at nominal concentrations of 0 (control, solvent control), 1.8, 3.2, 5.8, 10, 18, 32, 58 and 100 mg/L for 96-h under static conditions. The 96-h LC50 was 83 mg/L. The LC0 was 18 mg/L. However, high vehicle concentration was used and undissolved test item was observed in concentrations above 18mg/L and observed adverse effect could relate to this fact.


Thus, it can be concluded that the test substance is not acutely toxic to fish at the range of solubility.