Registration Dossier
Registration Dossier
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EC number: 203-696-6 | CAS number: 109-69-3
Specific investigations: other studies
Administrative data
- Endpoint:
- biochemical or cellular interactions
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: only short summary available; too few data for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Effect of Chlorinated Alkanes on Hepatic Triglyceride Secretion
- Author:
- Selan, F. M. and Evans, M. A.
- Year:
- 1 987
- Bibliographic source:
- Res. Commun. Chem. in Pathol. Pharmacol. 55, 249- 269
Materials and methods
- Principles of method if other than guideline:
- The effect of a series of monochloroalkanes on hepatic triglyceride secretion was investigated in male Swiss Webster mice and Spague Dawley rats in vitro and in vivo.
- GLP compliance:
- not specified
- Type of method:
- other: in vivo and in vitro
- Endpoint addressed:
- basic toxicokinetics
Test material
- Reference substance name:
- 1-chlorobutane
- EC Number:
- 203-696-6
- EC Name:
- 1-chlorobutane
- Cas Number:
- 109-69-3
- Molecular formula:
- C4H9Cl
- IUPAC Name:
- 1-chlorobutane
- Details on test material:
- - Name of test material (as cited in study report): 1-chlorobutane
Constituent 1
Test animals
- Species:
- other: rat and mouse
- Strain:
- other: SD rats and Swiss Webster mice
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- single treatment
- Frequency of treatment:
- once
- Post exposure period:
- no data
- No. of animals per sex per dose:
- no data
- Control animals:
- yes, concurrent vehicle
Results and discussion
- Details on results:
- 1-Chlorobutane produced a dose-related decrease in serum triglyceride levels at 2 hours after administration of different doses in corn oil (0.1 ml/kg bw). The dose necessary to produce a 50% decrease in in vivo triglyceride secretion was 43.9 mmol/kg (4.1 g/kg). The n-buyl chloride concentration required to produce a 50% decrease in triglyceride secretion by isolated hepatocytes was 24.7 mM (23 mg/mL).
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
