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EC number: 800-838-4 | CAS number: 1384855-91-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 14 Oct, 1980 to 28 Oct, 1980
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 40 CFR Part 163.81-2 (Environmental Protection Agency, Pesticides Programs, Proposed Guidelines for Registering Pesticides in the U.S.; Hazard Evaluation: Humans and Domestic Animals. Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- not specified
- Limit test:
- yes
Test material
- Reference substance name:
- 2-(hydroxymethyl)-2-[[(1-oxoallyl)oxy]methyl]-1,3-propanediyl diacrylate
- EC Number:
- 222-540-8
- EC Name:
- 2-(hydroxymethyl)-2-[[(1-oxoallyl)oxy]methyl]-1,3-propanediyl diacrylate
- Cas Number:
- 3524-68-3
- Molecular formula:
- C14H18O7
- IUPAC Name:
- 3-(acryloyloxy)-2-[(acryloyloxy)methyl]-2-(hydroxymethyl)propyl acrylate
- Reference substance name:
- 2-Propenoic acid, reaction product with pentaerythritol
- IUPAC Name:
- 2-Propenoic acid, reaction product with pentaerythritol
- Reference substance name:
- 2-Propenoic acid, reaction products with pentaerythritol
- EC Number:
- 629-850-6
- Cas Number:
- 1245638-61-2
- Molecular formula:
- Not available for this UVCB.
- IUPAC Name:
- 2-Propenoic acid, reaction products with pentaerythritol
- Test material form:
- liquid: viscous
- Details on test material:
- - Name of test material (as cited in study report): C171
- Physical state: Viscous clear liquid
- Analytical purity: Not mentioned in the report
- Expiration date of the lot/batch: 9/1/81
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- other: Albino rabbits
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Penn Dutch Laboratory animals, Denver, Pennsylvania
- Age at study initiation: Young adults
- Weight at study initiation: 2.2 to 2.8 kg (males), 2.5 to 2.9 kg (females)
- Housing: Individually housed
- Diet: Purina Rabbit Chow, ad libitum
- Water: Automatic watering system, ad libitum.Municipal water supply (Elizabethtown Water Co. )
ENVIRONMENTAL CONDITIONS
- Temperature: 60 to 66°F
- Photoperiod: 12 h light, 12 h dark
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- On the day before dosing (approx 18 h prior to dosing), the hair of each rabbit was closely clipped from the trunk with an electric clipper, so as to expose at least 10% of the body surface area. Just prior to dosing, the skin of all of the animals was abraded longitudinally every 2 or 3 cm over the area of exposure, deep enough to penetrate the stratum corneum, but not so deep as to disturb the dermis or produce bleeding. The test substance was applied directly onto the exposed skin of the animal, and spread evenly over the entire area. A layer of 8-ply gauze was then wrapped around the animal to cover the application site. The animal was then wrapped in an impervious plastic sleeve, designed to contain the test substance without leakage or undue pressure. The sleeve was secured with masking tape and Elizabethan collars were placed on all animals. Following approx 24 h of exposure, the wrappings were removed and the test site wiped free of excess test substance. After 30 min, dermal observations were made.
- Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 10 (six males, four females)
- Control animals:
- not required
- Details on study design:
- - Duration of observation period following administration: 14 d
- Frequency of observations and weighing: Approx 1, 2, and 4 h after dosing and daily thereafter for 14 d.
- Necropsy of survivors performed: Gross post mortem examinations were performed on all animals which died or were found dead during the study. All animals surviving at termination of the observation period (Day 14) were killed by an intravenous overdose of sodium pentobarbital and examined grossly. All abnormalities were recorded hut no tissues were saved.
- Other examinations performed: Clinical signs, body weight
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No
- Clinical signs:
- other: No
- Other findings:
- All animals exhibited well-defined to severe erythema with moderate or severe edema at 24 h. Two animals exhihited eschar at the dosing site
at terminal necropsy. Several animals exhibited nasal and/or oral or ocular discharge during the 14 d post-dose period. A single animal exhibited decreased food consumption and fecal staining of the abdomen at 24 h only.
Applicant's summary and conclusion
- Interpretation of results:
- other: EU CLP criteria not met
- Conclusions:
- Under the study conditions, the dermal LD50 of the test substance was determined to be >2,000 mg/kg bw in rabbits.
- Executive summary:
A study was conducted to determine the acute dermal toxicity of the test substance, PETIA in rabbits according to the EPA 40 CFR Part 163.81-2. A single dose of 2,000 mg/kg bw was administered at a dose volume of 1.7 mL/kg bw to ten rabbits (six males and four females). Following approximately 24 h of exposure, the wrappings were removed and the test site wiped free of excess test substance. After 30 min, dermal observations were made. No mortality occurred and most animals gained weight in the 14 d period after dosing although one male and one female exhibited weight loss. All animals showed well-defined to severe erythema with moderate or severe edema at 24 h. In two animals, eschar was seen at the dosing site at terminal necropsy. Several animals had nasal and/or oral or ocular discharge during the 14 d post-dose period. A single animal exhibited decreased food consumption and fecal staining of the abdomen at 24 h only. Under the study conditions, the dermal LD50 of the test substance was determined to be >2,000 mg/kg bw in rabbits (Auletta, 1980).
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