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EC number: 800-838-4
CAS number: 1384855-91-7
A study was
conducted to determine the acute dermal toxicity of the test substance,
PETIA in rabbits according to the EPA 40 CFR Part 163.81-2. A
single dose of 2,000 mg/kg bw was administered at a dose volume of 1.7
mL/kg bw to ten rabbits (six males and four females). Following
approximately 24 h of exposure, the wrappings were removed and the test
site wiped free of excess test substance. After 30 min, dermal
observations were made. No mortality occurred and most animals gained
weight in the 14 d period after dosing although one male and one female
exhibited weight loss. All animals showed well-defined to severe
erythema with moderate or severe edema at 24 h. In two animals, eschar
was seen at the dosing site at terminal necropsy. Several animals had
nasal and/or oral or ocular discharge during the 14 d post-dose period.
A single animal exhibited decreased food consumption and fecal staining
of the abdomen at 24 h only. Under the
study conditions, the dermal LD50 of the test substance was determined
to be >2,000 mg/kg bw in rabbits (Auletta, 1980).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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