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EC number: 227-534-9
CAS number: 5873-54-1
determine whether longitudinal declines in ventilatory capacity
and the occurrence of respiratory symptoms in workers
manufacturing polyurethane foam were related to toluene
diisocyanate (TDI) exposure.
earlier study, a population of workers from 12 UK factories was
studied between 1981 and 1986. A survivor cohort of 251, of whom
217 were in the 1981–1986 study, was examined again in 1997–1998.
Modified British Medical Research Council respiratory
questionnaires and lung function measurements were completed for
each of the 251 subjects at the beginning and end of the 17-year
study period. Mean TDI exposures for all jobs in which subjects
were employed were assessed and related to their occupational
annual declines in 1-second forced expiratory volume (FEV1)
and forced vital capacity (FVC) were not related to TDI exposure,
and were typical of those measured in other populations not
exposed to TDI. Over the study period the cold-foam handling group
showed an increase in breathlessness and a significant excess
decline in FVC; the exposed group (n=175)
showed an increase in wheezing (mainly smokers), whilst the
low-exposure group (n=50)
showed a decrease in chest illness. Smoking and an increase in
body weight both caused excess declines in FEV1.
this study does not provide evidence that there was any
TDI-related decline in FEV1
in FVC over a 17-year period in workers exposed to TDI at the
levels prevailing in the UK factories that manufactured flexible
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