Registration Dossier

Environmental fate & pathways

Endpoint summary

Administrative data

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Additional information

Due to the high reactivity of the substances of the MDI category with water, bioaccumulation tests can in principle not be performed with these substances. However, one bioaccumulation test (OECD 305E) with 4,4'-MDI and a mesocosm study with PMDI with an indication of bioaccumulation potential have been performed.

No data are available on terrestrial bioaccumulation on any of the MDIs of the category approach. The reactivity of MDI with water, the low measured BCF in fish and the evidence of the mesocosm study, suggest that MDI has a low potential to bioaccumulate in terrestrial food-chains.