Registration Dossier
Registration Dossier
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EC number: 204-602-6 | CAS number: 123-11-5
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: publication with limited documentation; no GLP; TS purity not specified;
Data source
Reference
- Reference Type:
- publication
- Title:
- STUDY OF ARTIFICIAL FLAVOURING SUBSTANCES FOR MUTAGENICITY IN THE SALMONELLA/MICROSOME, BASC AND MICRONUCLEUS TESTS
- Author:
- D.WILD; M.-T. KING; E . GOCKE and K. ECKHARDT
- Year:
- 1 983
- Bibliographic source:
- Fd Chem. Toxic.; Vol 21 , No 6, pp. 707-719
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)
- Deviations:
- yes
- Remarks:
- limited documentation
- GLP compliance:
- no
- Type of assay:
- micronucleus assay
Test material
- Reference substance name:
- 4-ethoxybenzaldehyde
- EC Number:
- 233-093-3
- EC Name:
- 4-ethoxybenzaldehyde
- Cas Number:
- 10031-82-0
- Molecular formula:
- C9H10O2
- IUPAC Name:
- 4-ethoxybenzaldehyde
- Details on test material:
- - Name of test material (as cited in study report): 4-Ethoxybenzaldehyde
No further data.
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- NMRI
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 10-14 weeks
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- - Vehicle(s)/solvent(s) used: olive oil
- Duration of treatment / exposure:
- 30 hours
- Frequency of treatment:
- 2 applications (0, 24hours)
- Post exposure period:
- not applicable
Doses / concentrations
- Remarks:
- Doses / Concentrations:
335; 670; 1005 mg/kg bw
Basis:
- No. of animals per sex per dose:
- 4 (sex not specified)
- Control animals:
- yes
- Positive control(s):
- No data
Examinations
- Tissues and cell types examined:
- bone marrow
- Details of tissue and slide preparation:
- No details given
- Evaluation criteria:
- No details given
- Statistics:
- No details given
Results and discussion
Test results
- Sex:
- male/female
- Genotoxicity:
- negative
- Toxicity:
- yes
- Vehicle controls validity:
- valid
- Negative controls validity:
- not specified
- Positive controls validity:
- not specified
Any other information on results incl. tables
Results of micronucleus test on mouse bone marrow
| Dose [mg/kg bw] | Surviving/treated mice | Mean no. of MNPE / 1000 PE |
| 1005 | 2/4 | 2.9 |
| 670 | 4/4 | 1.8 |
| 335 | 4/4 | 2.0 |
| 0 | 4/4 | 1.9 |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
