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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Scientifically acceptable publication

Data source

Reference
Reference Type:
publication
Title:
The Metabolism of Vetraldehyde and Veratric Acid in the Rabbit
Author:
Sammons HC and Williams RT
Year:
1945
Bibliographic source:
Biochemical Journal 40: 223-227

Materials and methods

Objective of study:
metabolism
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Determination of test substance metabolites in the urine after oral treatment.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Anisaldehyde
EC Number:
204-602-6
EC Name:
Anisaldehyde
Cas Number:
123-11-5
Molecular formula:
C8 H8 O2
IUPAC Name:
4-methoxybenzaldehyde
Test material form:
not specified
Details on test material:
- Name of test material (as cited in study report): anisaldehyde; p-methoxybenzaldehyde
No additional details provided.
Radiolabelling:
no

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No additional details provided.

Administration / exposure

Route of administration:
oral: feed
Vehicle:
unchanged (no vehicle)
Details on exposure:
No additional details provided
Duration and frequency of treatment / exposure:
Not specified
Doses / concentrations
Remarks:
Doses / Concentrations:
2000 mg per animal
No. of animals per sex per dose / concentration:
a total of 6 animals (sex not specified)
Control animals:
not specified
Details on dosing and sampling:
METABOLITE CHARACTERISATION STUDIES
- Tissues and body fluids sampled: urine
- Time and frequency of sampling: the urine was collected during 24 hours

Results and discussion

Metabolite characterisation studies

Metabolites identified:
yes
Details on metabolites:
Anisoylglucuronide was prepared from the 24-hour urine anisaldehyde-fed rabbits.

Applicant's summary and conclusion