Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Additional information

Skin irritation:

The QSAR study carried out with Toxtree v.2.5.0 (2011), based on a decision support system (DSS) developed by the German Federal Institute for Risk Assessment (BfR) uses physico-chemical exclusion rules, excludes the potential activity irritating or corrosive to skin of betamethasone. The prediction is based on the exclusion rule that Melting Point[°C] is > 200.

Eye irritation:

The QSAR study carried out with Toxtree v.2.5.0 (2011), based on a decision support system (DSS) developed by the German Federal Institute for Risk Assessment (BfR) uses physico-chemical exclusion rules, excludes the potential activity irritating or corrosive to eye of prednisolone. The prediction is based on the exclusion rule, of the skin irritation/corrosion endpoint, that Melting Point[°C] is > 200. Because of prednisolone is neither irritating nor corrosive to skin, the DDS did not evaluate prednisolone for eye irritation potency.

Betamethasone is a compound of the most powerful and used to treat eye and skin inflammation.

Justification for classification or non-classification

In accordance to Directive 67/548/EEC and Regulation 1272/2008/EC, classification is not necessary for irritation / corrosion based on the available data.