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EC number: 207-837-2 | CAS number: 497-18-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 0.002 mg/L
- Assessment factor:
- 1 000
- Extrapolation method:
- assessment factor
- PNEC freshwater (intermittent releases):
- 0.015 mg/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 0 mg/L
- Assessment factor:
- 10 000
- Extrapolation method:
- assessment factor
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 2.5 mg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- no exposure of sediment expected
Sediment (marine water)
- Hazard assessment conclusion:
- no exposure of sediment expected
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- no exposure of soil expected
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- no potential for bioaccumulation
Additional information
A long-term 7-day static-renewal Ceriodaphnia dubia chronic test was conducted on the substance. However, the results of this study have not been used to derive PNECs, nor reduce assessment factors, as algae is considered the most sensitive species based on the acute toxicity data.
Conclusion on classification
The environmental classification of the substance has been assessed based on the results of testing in algae, Daphnia and fish, biodegradation and bioaccumulation data and physico-chemical data (water solubility, octanol-water partition coefficient).
In acute toxicity testing in algae, Daphnia and fish, the most sensitive species (giving the lowest E(L)C50) was the algae, Pseudokirchnerella subcapitata, which gave a 72 hour ErC50 (based on growth rate) of 1.5 mg/l.
As classification for algal studies is based on the growth rate parameter, the substance does not meet the criteria for classification in Acute Category 1 (72 or 96 hr ErC50 for algae <1 mg/l), as the result is greater than 1 mg/l.
The substance is highly water soluble, readily biodegradable, has a very low partition coefficient (log Kow -2.94) and has an experimentally determined bioconcentration factor (BCF) of ≤6.
Based on the acute toxicity results and these properties, the substance would not meet the criteria for environmental classification in chronic categories 1, 2, 3 or 4.
However, in addition to the acute toxicity data one chronic/long-term study is available, a 7 -day static-renewal Ceriodaphnia dubia chronic toxicity study. This study gave the following results:
NOEC (7 d): 3.93 mg/L act. ingr. (nominal) based on: survival
NOEC (7 d): 0.98 mg/L act. ingr. (nominal) based on: reproduction
For rapidly degradable substances for which adequate chronic toxicity data is available, a Chronic Category 3 classification may apply if the chronic NOEC is >0.1 to ≤1 mg/l.
Based on the NOEC for reproduction (0.98 mg/l) this classification could apply.
However, as the NOEC (reproduction) result of 0.98 mg/l is so close to the 1 mg/l cut-off for classification, and that the NOEC based on survival is substantially above 1 mg/l, it is considered classification may not be appropriate. Normal biological differences between animals can account for slight differences in test results i.e. further 7 -day static-renewal Ceriodaphnia dubia chronic toxicity studies could be expected to show some NOEC (reproduction) results at greater than 1 mg/l, taking into account differences between animals, slight variations in test water/medium, slight variations in test sample.
In addition, although the ceriodaphnia dubia study is considered to be a valid study and appropriate for evaluation of chronic/long-term toxicity based on the lifecycle of ceriodaphna dubia, it is not the standard long-term Daphnia reproduction study (OECD Guideline 211 (Daphnia magna Reproduction Test) conducted.
Based on evaluation of all the above data, it is therefore proposed that the substance should not currently be classified for the environment.
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