Registration Dossier
Registration Dossier
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EC number: 232-218-9 | CAS number: 7790-69-4
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption, other
- Remarks:
- expert statement
- Type of information:
- other: expert statement
- Adequacy of study:
- key study
- Study period:
- 2013
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- other: expert statement
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- The absorption of lithium nitrate through skin is considered to be very poor. 10 % absorption was used for DNEL deduction representing a worst case.
- Executive summary:
The stratum corneum provides its greatest barrier function against hydrophilic compounds, whereas the viable epidermis is most resistant to highly lipophilic compounds. When considering lithium nitrate it can be expected that the uptake will be limited and practically excluded. This is due to the hydrophilic character of lithium nitrate and the barrier function of the stratum corneum against ions. This is supported by an acute dermal toxicity study that revealed a LD50 value of > 2000 mg/kg bw without any local or systemic effects. Further no sensitisation could be detected in a maximisation test with guinea pigs. This supports the conclusion of a very limited absorption of lithium nitrate through the skin. In conclusion, upon dermal contact, the absorption of lithium nitrate through skin and its bioavailability are considered to be very poor.
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