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EC number: 204-876-7 | CAS number: 128-04-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The chemical safety assessment carried out according to Annex I of Regulation (EC) No 1907/2006 does not indicate the need to further investigate the long-term toxicity to fish.
Key value for chemical safety assessment
Additional information
Experimental data for the long-term toxicity of sodium dimethyldithiocarbamate (SDDC, CAS No. 128-04-1) to fish are not available. However, the chemical safety assessment according to Annex I of REACH Regulation (EC) No 1907/2006 does not indicate the need to further investigate the long-term toxicity to fish. Thus, and for reasons of animal welfare, long-term testing on fish is not proposed, in accordance with Annex X, 9.4, column 2.
According to the Guidance on information requirements and chemical safety assessment Chapter R.7b, section R.7.8.5.3 (ECHA, 2017) long-term testing on fish should only be conducted if fish represent the most sensitive taxonomic group. Furthermore, the guidance states that if aquatic invertebrates are likely to be more sensitive than fish and algae or the relative sensitivity of invertebrates cannot be predicted, long-term testing on Daphnia sp. should be preferred instead of fish.
Experimental data for the short-term aquatic toxicity of SDDC are available for all three trophic levels and provide strong evidence that fish are not the most sensitive taxonomic group. Based on the available short-term aquatic toxicity data, aquatic algae are the most sensitive taxonomic group by a factor of 100 with an ErC50 (72 h) of 0.0012 mg a.i./L relative to aquatic invertebrates with an EC50 (48 h) of 0.68 mg a.i./L and fish with a LC50 (96 h) of 0.76 mg a.i./L.
Experimental data for the long-term aquatic toxicity of SDDC are available for two trophic levels, namely for aquatic algae and invertebrates, as recommended by the guidance document. Based on the available long-term aquatic toxicity data, aquatic algae are the most sensitive taxonomic group by a factor of 10 with an ErC10 (72 h) of 0.00074 mg a.i./L relative to aquatic invertebrates with a NOEC (21 d) of 0.0095 mg a.i./L, thus confirming the same trend observed for the short-term aquatic toxicity of SDDC.
Furthermore, the environmental exposure assessment with PNEC values derived from the available ecotoxicological studies resulted in Risk Characterisation Ratios (RCR) clearly below 1 indicating a low risk to the aquatic ecosystem.
Since both short-term and long-term aquatic toxicity data clearly indicate that aquatic algae are the most sensitive taxonomic group for the aquatic toxicity of SDDC, a long-term test with fish is not expected to significantly deviate from this overall ecotoxicological profile. Therefore, and for reasons of animal welfare, long-term testing on fish is not proposed and the current dataset is considered to be sufficient.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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