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EC number: 284-892-9 | CAS number: 84989-04-8 The fraction of tar acid rich in 3- and 4-methylphenol, recovered by distillation of low-temperature coal tar crude tar acids.
RS-Freetext:600 mg/kg bw/day: mortality 19/30 females and 9/30 males, Body weight:
body weight of females were unaffected
600 mg/kg bw/d, males: significant during week 2 through 10
175 mg/kg bw/d, males: significant during week 2
Body weight gain
175 and 600 mg/kg bw/d
reduction in body weight gain (males), slight decrease in food intake;
600 mg/kg bw/day, males and females,
175 mg/kg bw/d: 1 female d23 and 1 female d27Treatment-related depression of the central nervous system:lethargy, dyspnoe, tremor and/or convulsions, recoveringwithin 1 h after dosing
no effects on clinical chemistry, hematology, urinalyses parameters, no treatment-related ophthalmic lesions, no effects on organ weights, no treatment-related gross and histomorphologic
According to Sontag JM, Page NP, Saffotti U, NCI, DHEW Publication No (NIH)78-ß01 Guidelines for Carcinogen Bioassay in small rodents) male and female rats were applied with 0, 50,175, 600 mg/kg bw/day by gavage for 13 weeks. The NOAEL is 50 mg/kg bw/day based on clinical signs and effects on body weights from 175 mg/kg bw /day onwards..
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