Triphenylphosphine

Eye irritation

Administrative data

Endpoint:

eye irritation: in vivo

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: screening test: discrepancy between documented test parameters and standard methods, but scientifically acceptable

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1952

Report date:

1952

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

- Principle of test: Detection of eye irritation using BASF-internal standards. Two drops of a 10 % preparation of the test substance in olive oil were inserted in a time interval of 5 min into the conjunctival sac of the left eye and carefully distributed on the eye surface. Olive oil was applied to the other eye as control. The eyes were not rinsed after application. Readings were done after 10 min, 1 h, 3 h and 24 h and the animals were observed further until recovery.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Triphenylphosphine

EC Number:

210-036-0

EC Name:

Triphenylphosphine

Cas Number:

603-35-0

Molecular formula:

C18H15P

IUPAC Name:

triphenylphosphine

Test material form:

solid: crystalline

Test animals / tissue source

Species:

rabbit

Strain:

not specified

Test system

Vehicle:

other: olive oil

Controls:

yes, concurrent negative control

Amount / concentration applied:

TEST MATERIAL
- Amount(s) applied (volume or weight with unit): two drops.
- Concentration (if solution): 10% in olive oil.

Observation period (in vivo):

10 min, 1 h, 3 h and 24 h further observation until potential effects are reversible.

Number of animals or in vitro replicates:

2

Results and discussion

In vivo

Irritant / corrosive response data:

Erythema were observed after 10 min and erythema/edema after 1 and 3 hours in 2/2 animals, which were fully reversible after 24 hours.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Executive summary:

Two drops of a 10 % preparation of the test substance in olive oil were inserted in a time interval of 5 min into the conjunctival sac of the left eye of two rabbits. Olive oil was applied to the other eye as control. The eyes were not rinsed after application. Readings were done after 10 min, 1 h, 3 h and 24 h and the animals were observed further until recovery.

2/2 animals showed erythema after 10 min and erythema/edema after 1 and 3 hours, which were fully reversible after 24 hours.