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The urinary excretion of unmetabolized sulfolane was studied in male Sprague-Dawley rats from a single intravenous injection of 500 or 1,000 mg/kg sulfolane (Andersen et al., 1976). The proportion of dose excreted unchanged increased as the dosage was increased. In a separate set of experiments, the elimination of sulfolane from the blood was determined in a rabbit, dog and squirrel monkey following a single intravenous doses of sulfolane. Sulfolane was rapidly distributed with volumes of distribution of about 1.0 L/kg; the elimination half-life was 3.5 to 5 hours. 

Andersen, M.E., Jones, R.A., Kurlansik, L., Mehl, R.G., and Jenkins, L.J., Jr. (1976) Sulfolane-induced convulsions in rodents. Res. Commun. Chem. Pathol. Pharmacol. 15: 571-580.

[35S]-Sulfolane (100 mg) was injected intraperitoneally into three male Wistar rats and the 24-hour urinary samples were analysed (Roberts and Warwick, 1961). One major metabolite was excreted, constituting at least 85% of the urinary radioactivity. It was identified as 3-hydroxysulfolane. 

Roberts, J.J., and Warwick, G.P. (1961) The mode of action of alkylating agents – III The formation of 3-hydroxytetrahydrothiophene-1;1-dioxide from 1:4-dimethylsulphonyloxybutane (Myleran), S-β-L-alanyltetrahydrothiophenium mesylate, tetrahydrothiophene and tetrahydrothiophene-1:1-dioxide in the rat, rabbit and mouse. Biochem. Pharmacol. 6: 217-227.