Registration Dossier

Administrative data

Endpoint:
sub-chronic toxicity: inhalation
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Secondary literature Documentation insufficient for assessment Original reference not available

Data source

Reference
Reference Type:
publication
Title:
Dimethyl sulphide
Author:
Opdyke DLJ
Year:
1979
Bibliographic source:
Food and Cosmetics Toxicology, 17(4), pp 365-368

Materials and methods

Principles of method if other than guideline:
Data not available
GLP compliance:
no
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Dimethyl sulphide (no other information available)

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
data not available

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
other: no data
Details on inhalation exposure:
data not available
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
6 months
Frequency of treatment:
6 h/day
Doses / concentrations
Remarks:
Doses / Concentrations:
5 and 25 mg/m3
Basis:
no data
No. of animals per sex per dose:
15 males and 15 females
Control animals:
not specified
Details on study design:
Post-exposure period: no data
Positive control:
data not available

Examinations

Observations and examinations performed and frequency:
data not available
Sacrifice and pathology:
data not available
Other examinations:
data not available

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

25 mg/m3 : Decrease in weight gain, increase in heart weight, disorders of corticosteroid distribution in the adrenal tissue, a decrease in oxygen consumption and carbon dioxide elimination, decreases in catalase activity and the methaemoglobin and phospholipid levels in the blood, and increases in pyruvic acid, lactic acid and thiol groups in whole blood and in tissue homogenates. Increased cholesterol levels in  the blood serum.
5 mg/m3 : temporary changes (no detail available)

Applicant's summary and conclusion