Registration Dossier

Toxicological information

Developmental toxicity / teratogenicity

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Administrative data

Endpoint:
developmental toxicity
Type of information:
(Q)SAR
Adequacy of study:
supporting study
Rationale for reliability incl. deficiencies:
other: OECD Toolbox Category Approach based on data from 17 related substances.
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
other: OECD Toolbox
Title:
Guidance Document on the Validation of (Quantitative) Structure-Activity Relationships Models
Author:
OECD
Year:
2007
Bibliographic source:
OECD, Publisher. September, 2007

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
The OECD Toolbox Category Approach was used and the OECD profilers for DNA OASIS and Estrogen Receptor Binding were calculated. Reproductive and developmental toxicity endpoints were of interest for this analysis. They included teratogenicity, gene mutation, chromosomal aberration, and relative ERBA.

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Results (fetuses)

Fetal abnormalities

Abnormalities:
not specified

Overall developmental toxicity

Developmental effects observed:
not specified

Applicant's summary and conclusion