Registration Dossier
Registration Dossier
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EC number: 202-592-8 | CAS number: 97-59-6
Endpoint summary
Administrative data
Description of key information
No eye or skin irritation was reported in reliable eye and skin irritation studies on Allantoin.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Study is a reliable OECD guideline study conducted under GLP.
Justification for selection of eye irritation endpoint:
The study was performed at the Centre International de Toxicologie (C.I.T.) in accordance with the protocol agreed upon by Societe Francaise Hoechst (dated 21 September 1984), published in the Journal Officiel de la Republique Francaise (J.O.R.F., dated 24 October 1984) and the Principles of Good Labor Practice (GLP).
Justification for classification or non-classification
Based on reliable in vivo skin and eye irritation data, Allantoin does not meet the criteria for classification as irritant according to EU Directive 67/548/EEC and Regulation 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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