Registration Dossier
Registration Dossier
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EC number: 201-853-3 | CAS number: 88-72-2
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- adult fish: sub(lethal) effects
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- Study meets basic scientific principles. Basic data given.
- Principles of method if other than guideline:
- - Test similar to the method described by Canton and Slooff (1982) [Canton, JH and Slooff, W (1982): Substitutes for phosphate containing washing products: their toxicity and biodegradability in the aquatic environment. Chemosphere 11 (9): 891 - 907]
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 2-Nitrotoluene
- Analytical purity: > 99.5%
- Supplier: Fluka - Test organisms (species):
- Oryzias latipes
- Duration:
- 28 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 1.9 mg/L
- Basis for effect:
- other: mortality and behavior
- Duration:
- 28 d
- Dose descriptor:
- LC50
- Effect conc.:
- 9.4 mg/L
- Duration:
- 28 d
- Dose descriptor:
- EC50
- Effect conc.:
- 9.4 mg/L
- Basis for effect:
- other: mortality and behavior
- Validity criteria fulfilled:
- not specified
- Executive summary:
Canton, 1985
The long-term toxicity of the test item 2-nitrotoluene towards Oryzias latipes was tested in a semi-static setup. The following effect concentrations were observed: LC50 (28 days): 9.4 mg/L, EC50 (28 days, based on mortality and behavior): 9.4 mg/L, NOEC (28 days, based on mortality and behavior): 1.9 mg/L.
Reference
Description of key information
For transported isolated intermediates according to REACh, Article 18, this endpoint is not a data requirement. However, data is available for this endpoint and is thus reported under the guidance of "all available data".
Canton, 1985
The long-term toxicity of the test item 2-nitrotoluene towards Oryzias latipes was tested in a semi-static setup. The following effect concentrations were observed: LC50 (28 days): 9.4 mg/L, EC50 (28 days, based on mortality and behavior): 9.4 mg/L, NOEC (28 days, based on mortality and behavior): 1.9 mg/L.
Key value for chemical safety assessment
Additional information
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