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EC number: 215-271-2 | CAS number: 1317-40-4
Justification of the read-across from copper (II) oxide to copper sulphide:
Acute oral toxicity:
A GLP-compliant acute oral toxicity study was conducted with the read-across compound copper (II) oxide using male rats, in accordance with OECD Guideline 423 (Sanders, 2002a). The LD50 value obtained was > 2500 mg/kg bw. It is therefore concluded that copper sulphide is not classified on the basis of acute oral toxicity.
Acute inhalation toxicity:
Copper sulphide has an extremely low calculated mass solubility in the range 3.31E-11 mg/L to 2.40E-10 mg/L. Any inhaled material will also be insoluble in lung fluid, with negligible bioavailability or potential to cause toxicity. Compounds with low solubility in lung fluid have been shown not to require classification on the basis of acute inhalation toxicity. It is considered that copper sulphide aligns with this category of copper compounds and should therefore not be classified. This approach is consistent with sound scientific principles and the obligation to avoid animal testing whenever possible.
Acute dermal toxicity:
A GLP-compliant acute dermal toxicity study was conducted with the read-across compound copper (II) oxide using male and female rats in accordance with OECD Guideline 402 (Sanders, 2002b). The LD50 value obtained was > 2000 mg/kg bw. It is therefore concluded that copper sulphide is not classified on the basis of dermal toxicity.
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